Militants killed 14 policemen and wounded eight in a shootout during a raid Friday on a militants' hideout southwest of Cairo, an Egyptian security official said.
Authorities are fighting the Egyptian branch of the self-styled Islamic State terrorist group, which has increased its attacks in the north of the Sinai peninsula more than 500 kilometers (300 miles) away from the latest violence.
The interior ministry released a statement on the operation on Friday but has so far not given any details on casualties.
The security sources put the death toll of policemen, including officers and conscripts, at over 50.
The statement said that the forces were looking for terrorists in the surrounding areas. The group has claimed responsibility for several attacks around Cairo, targeting judges and police officers over the past year.
Up to 52 officers killed in shoot-out with fighters in Giza governorate in fresh blow to security forces. Clashes erupted when they tried to arrest them and they exchanged fire.
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Hundreds of police and army personnel have been killed since then.
Officials said, the policemen were killed in exchange of fire with the terrorists in el-Wahat desert in Giza yesterday. The Muslim Brotherhood denies this.
In their statements, none of the militant groups claim any affiliation to the Muslim Brotherhood.
The militant group staging the insurgency pledged allegiance to ISIS in 2014.
A fake claim in the name of the small extremist group Hasm, reported by multiple local media, spread on social media soon after the attack.
Egypt has been under a state of emergency since bombings and suicide attacks targeting minority Coptic Christians killed scores earlier this year.