Sean was perhaps best known for his role as a team captain in the early years of BBC2 music comedy panel show Never Mind The Buzzcocks, where he appeared alongside Mark Lamarr, Phil Jupitus and an ever-changing line-up of celebrity guests.
He was the youngest ever victor of the Perrier award in 1990 with his show A One Night Stand With Sean Hughes.
In his last tweet, on October 8, he said he had gone to hospital. But the stage always came calling him back and not always just for stand-up.
As well as being an established comedian, he also made several appearances as an actor in his career, including a minor role in the cult 1991 movie The Commitments.
"I have been blessed with decent health, even though I have pushed my body to extreme hedonistic limits".
Sarah Millican added: "So sad to hear of Sean Hughes death".
According to reports, Hughes' death was caused by liver cirrhosis, a condition caused by long-term liver damage. A brilliant comic and a lovely bloke.
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Popular Irish comedian Sean Hughes has passed away.
Irish comedian Dara O Briain said: 'Ah, that is very sad news.
"I am a huge fan of his and am very sad to hear this news".
Irish writer Paul Howard said, "Irish comedy in the 1990s".
He wrote best-selling novels The Detainees and It's What He Would Have Wanted.
He is survived by his two brothers, Alan and Martin.