It seems like the worst case scenario will be realized for the Giants. The injury looked very serious and considering how much pain Beckham was showing the Giants will be holding their breath.
Eli Manning fumbled on the next play and Los Angeles turned that turnover into a score three plays later.
Jordan Raanan of ESPN.com reports that Beckham will require surgery.
Earlier in the game both Marshall and Shepard left with ankle injuries on separate plays in the half and did not return.
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Marshall was also carted off the field in the second quarter after failing to make a one-handed catch and rolling his left ankle. Orleans Darkwa scored on a 23-yard run and the Giants got a safety in scoring their first first-quarter points this season.
Beckham went down on a pass that fell incomplete with about 4 minutes left in the game, the Giants up 22-20 at the time. He was seen after the game being carted out of the Giants' locker toom.
Chargers: at Oakland next Sunday. The second-year wide receiver came into Sunday leading the Giants with 21 catches for 254 yards and a touchdown.